免疫部門

業績

2016年

Onodera A, Yayama K, Tanaka A, Morosawa H, Furuta T, Takeda N, Kakiguchi K, Yonemura S, Yanagihara I, Tsutsumi Y, Kawai Y. Amorphous nanosilica particlesevoke vascular relaxation through PI3K/Akt/eNOS signaling. Fundam Clin Pharmacol.2016 May 23. doi: 10.1111/fcp.12206. [Epub ahead of print] PubMed PMID: 27214102.

Namba F, Kobayashi-Miura M, Goda T, Nakura Y, Nishiumi F, Son A, Kubota A, Yodoi J, Yanagihara I. Human thioredoxin-1 attenuates the rate of lipopolysaccharide-induced preterm delivery in mice in association with its anti-inflammatory effect. Pediatr Res. 2016 May 25. doi: 10.1038/pr.2016.100.[Epub ahead of print] PubMed PMID: 27100048.

Saka R, Wakimoto T, Nishiumi F, Sasaki T, Nose S, Fukuzawa M, Oue T, Yanagihara I, Okuyama H. Surfactant protein-D attenuates the lipopolysaccharide-induced inflammation in human intestinal cells overexpressing toll-like receptor 4. Pediatr Surg Int. 2016 Jan;32(1):59-63. doi:10.1007/s00383-015-3812-y. Epub 2015 Oct 28. PubMed PMID: 26510735.

2015年

Yokoi S, Ishihara N, Miya F, Tsutsumi M, Yanagihara I, Fujita N, Yamamoto H, Kato M, Okamoto N, Tsunoda T, Yamasaki M, Kanemura Y, Kosaki K, Kojima S, Saitoh S, Kurahashi H, Natsume J. TUBA1A mutation can cause a hydranencephaly-like severe form of cortical dysgenesis. Sci Rep. 2015 Oct 23;5:15165. doi:10.1038/srep15165. PubMed PMID: 26493046; PubMed Central PMCID: PMC4615979.

Taniguchi K, Nakayama M, Nakahira K, Nakura Y, Kanagawa N, Yanagihara I, Miyaishi S. Sudden infant death due to Lactococcal infective endocarditis. Leg Med (Tokyo). 2016 Mar;19:107-11. doi: 10.1016/j.legalmed.2015.07.013. Epub 2015Jul 26. PubMed PMID: 26277368.

Wakimoto T, Uchida K, Mimura K, Kanagawa T, Mehandjiev TR, Aoshima H, Kokubo K, Mitsuda N, Yoshioka Y, Tsutsumi Y, Kimura T, Yanagihara I. Hydroxylated fullerene: a potential antiinflammatory and antioxidant agent for preventing mouse preterm birth. Am J Obstet Gynecol. 2015 Nov;213(5):708.e1-9. doi:10.1016/j.ajog.2015.07.017. Epub 2015 Jul 18. PubMed PMID: 26196453.

Kawai Y, Nakura Y, Wakimoto T, Nomiyama M, Tokuda T, Takayanagi T, Shiraishi J, Wasada K, Kitajima H, Fujita T, Nakayama M, Mitsuda N, Nakanishi I, Takeuchi M, Yanagihara I. In vitro activity of five quinolones and analysis of the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum clinical isolates from perinatal patients in Japan. Antimicrob Agents Chemother. 2015 Apr;59(4):2358-64. doi: 10.1128/AAC.04262-14. Epub 2015 Feb 2. PubMed PMID: 25645833; PubMed Central PMCID: PMC4356753.

Saka R, Yanagihara I, Sasaki T, Nose S, Takeuchi M, Nakayama M, Okuyama H.Immunolocalization of surfactant protein D in the liver from infants with cholestatic liver disease. J Pediatr Surg. 2015 Feb;50(2):297-300. doi:10.1016/j.jpedsurg.2014.11.020. Epub 2014 Nov 10. PubMed PMID: 25638623.

名倉由起子、柳原格「ウレアプラズマの脅威 ~過剰な免疫反応が流早産を引き起こす~」(総説)大阪府立母子保健総合医療センター雑誌31(1), 2015

2014年

Wu HN, Nakura Y, Motooka D, Nakamura S, Nishiumi F, Ishino S, Kawai Y, Tanaka T, Takeuchi M, Nakayama M, Fujita T, Yanagihara I. Complete Genome Sequence of Ureaplasma parvum Serovar 3 Strain SV3F4, Isolated in Japan. Genome Announc. 2014 May 22;2(3). pii: e00256-14. doi: 10.1128/genomeA.00256-14. PubMed PMID: 24855292; PubMed Central PMCID: PMC4031331.

2013年

Uchida K, Nakahira K, Mimura K, Shimizu T, De Seta F, Wakimoto T, Kawai Y, Nomiyama M, Kuwano K, Guaschino S, Yanagihara I. Effects of Ureaplasma parvum lipoprotein multiple-banded antigen on pregnancy outcome in mice. J Reprod Immunol. 2013 Dec;100(2):118-27. doi: 10.1016/j.jri.2013.10.001. Epub 2013 Oct 19. PubMed PMID: 24238827.

Nakahira K, Morita A, Kim NS, Yanagihara I. Phosphorylation of FOXP3 by LCK downregulates MMP9 expression and represses cell invasion. PLoS One. 2013 Oct 14;8(10):e77099. doi: 10.1371/journal.pone.0077099. eCollection 2013. PubMed PMID: 24155921; PubMed Central PMCID: PMC3796550.

Hamaguchi M, Kamikubo H, Suzuki KN, Hagihara Y, Yanagihara I, Sakata I, Kataoka M, Hamada D. Structural basis of α-catenin recognition by EspB from enterohaemorrhagic E. coli based on hybrid strategy using low-resolution structural and protein dissection. PLoS One. 2013 Aug 14;8(8):e71618. doi:10.1371/journal.pone.0071618. eCollection 2013. PubMed PMID: 23967227; PubMed Central PMCID: PMC3743801.

Shigeta N, Ozaki K, Hori K, Ito K, Nakayama M, Nakahira K, Yanagihara I. An Arthrobacter spp. bacteremia leading to fetal death and maternal disseminated intravascular coagulation. Fetal Pediatr Pathol. 2013 Feb;31(1):25-31. doi:10.3109/15513815.2012.659413. Epub 2012 Apr 16. PubMed PMID: 22506930.

Kawai Y, Miyashita N, Kubo M, Akaike H, Kato A, Nishizawa Y, Saito A, Kondo E, Teranishi H, Wakabayashi T, Ogita S, Tanaka T, Kawasaki K, Nakano T, Terada K, Ouchi K. Nationwide surveillance of macrolide-resistant Mycoplasma pneumonia infection in pediatric patients. Antimicrob Agents Chemother. 2013;57(8):4046-9.

Miyashita N, Kawai Y, Akaike H, Teranishi H, Ouchi K, Okimoto N. Transmission of macrolide-resistant Mycoplasma pneumoniae within a family. J Infect Chemother. 2013;19(6):1196-201.

Miyashita N, Akaike H, Teranishi H, Kawai Y, Ouchi K, Kato T, Hayashi T, Okimoto N. Diagnostic value of symptoms and laboratory data for pertussis in adolescent and adult patients. BMC Infect Dis. 2013;13:129.

Miyashita N, Kawai Y, Akaike H, Teranishi H, Ouchi K, Okimoto N. Atelectasis caused by macrolide-resistant Mycoplasma pneumoniae pneumonia in an adult patient. J Infect Chemother. 2013;19(6):1161-6.

Kawai Y, Miyashita N, Kubo M, Akaike H, Kato A, Nishizawa Y, Saito A, Kondo E, Teranishi H, Ogita S, Tanaka T, Kawasaki K, Nakano T, Terada K, Ouchi K. Therapeutic efficacy of macrolides, minocycline, and tosufloxacin against macrolide-resistant Mycoplasma pneumoniae pneumonia in pediatric patients. Antimicrob Agents Chemother. 2013;57(5):2252-8.

Xiao SJ, Wang LY, Kimura M, Kojima H, Kunimoto H, Nishiumi F, Yamamoto N, Nishio K, Fujimoto S, Kato T, Kitagawa S, Yamane H, Nakajima K, Inoue A. S1-1/RBM10: Multiplicity and cooperativity of nuclear localisation domains. Biol Cell. 2013;105(4):162-74. Epub 2013 Feb 15.

脇本哲、柳原格.「妊娠期におけるプロゲステロンの働き~陣痛、早産に対する働き~」.大阪府立母子保健総合医療センター雑誌、第28巻、第1号、7-11、2013

2012年

Namba F, Ina S, Kitajima H, Yoshio H, Mimura K, Saito S, Yanagihara I. Annexin A2 in amniotic fluid: Correlation with histological chorioamnionitis, preterm premature rupture of membranes, and subsequent preterm delivery.TheJournal of Obstetrics and Gynaecology Research, 38(1), 137-44, 2012

Sakamoto S, Wakae K, Anzai Y, Murai K, Tamaki N, Miyazaki M, Miyazaki K, Romanow WJ, Ikawa T, Kitamura D, Yanagihara I, Minato N, Murre C, Agata Y. E2A and CBP/p300 Act in Synergy To Promote Chromatin Accessibility of the Immunoglobulin κ Locus. J Immunol, 188(11), 5547-60, 2012

Morita A, Nakahira K, Hasegawa T, Uchida K, Taniguchi Y, Takeda S, Toyoda A, Sakaki Y,Shimada A, Takeda H, Yanagihara I. Establishment and characterization of Roberts Syndrome and SC phocomelia model medaka, Oryziaslatipes. Dev Growth Differ, 54(5), 588-604, 2012

2011年

Mitobe J, Yanagihara I, Ohnishi K, Yamamoto S, Ohnishi M, Ishihama A, Watanabe H.RodZ regulates the post-transcriptional processing of the Shigellasonneitype III secretion system. EMBO reports, 12(9), 911-6, 2011

Mimura K, Tomimatsu T, Minato K, Jugder O, Kinugasa-Taniguchi Y, Kanagawa T, Nozaki M, Yanagihara I, KimuraT.Ceftriaxone preconditioning confers neuroprotection in neonatal rats through glutamate transporter 1 upregulation. Reproductive Sciences, 18(12), 1193-201, 2011

Yamashita K, Yoshioka Y, Higashisaka K, Mimura K, Morishita Y, Nozaki M, Yoshida T, Ogura T, Nabeshi H, Nagano K, Abe Y, Kamada H, Monobe Y, Imazawa T, Aoshima H, Shishido K, Kawai Y, Mayumi T, Tsunoda S, Itoh N, Yoshikawa T, Yanagihara I, Saito S, Tsutsumi Y. Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. Nature Nanotechnology, 6(5), 321-8, 2011

Nozaki M, Wakae K, Tamaki N, Sakamoto S, Ohnishi K, Uejima T, Minato N, Yanagihara I, Agata Y. Regulation of TCR Vγ2 Gene Rearrangement by the Helix-Loop-Helix Protein, E2A. International immunology, 23(5), 297-305, 2011

Ohnishi K, Nakahira K, Unzai S, Mayanagi K, Hashimoto H, Shiraki K, Honda T, Yanagihara I. Relationship between heat-induced fibrillogenicity and hemolytic activity of thermostable direct hemolysin and a related hemolysin of Vibrio parahaemolyticus. FEMS microbiology letters, 318(1),10-7, 2011

Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Markoff A, Yanagihara I, Udagawa Y, Kurahashi H. Polymorphisms in the annexinA5 gene promoter in Japanese women with recurrent pregnancy loss. Mol Hum Reprod, 17(7),447-52, 2011

中平久美子、柳原格. 「細菌毒素100年の謎を解く」.科学と生物、49(6)、366-7、2011

岩田みさ子、和栗雅子、中西功、光田信明、中山雅弘、柳原格.「ウレアプラズマ陽性例への乳酸菌製剤投与の試み」.大阪府立母子保健総合医療センタ-雑誌、第27巻、第1号・第2号、2011

齋藤滋、杉浦真弓、丸山哲夫、田中忠夫、竹下俊行、山田秀人、小澤伸晃、中塚幹也、木村正、藤井知行、下屋浩一郎、山本樹生、佐田文宏、廉東天、早川智、一瀬白帝、柳原格、秦健一郎、勝山博信、堤康央、中野有美、福井淳史、杉俊隆.「不育症over view」.産婦人科の実際、60(10)、1401-8、2011

2010年

Yanagihara I, Nakahira K, Yamane T, Kaieda S, Mayanagi K, Hamada D, Fukui T, Ohnishi K, Kajiyama S, Shimizu T, Sato M, Ikegami T, Ikeguchi M, Honda T, Hashimoto H. Structure and functional characterization of Vibrio parahaemolyticus thermostable direct hemolysin. The Journal of Biological Chemistry, 285(21), 16267-74, 2010

Nishihara M, Sonoda M, Matsunami K, Yanagihara K, Yonemoto N, Ida S, Namba F, Shimomura I, Yanagihara I, Waguri M. Birth length is a predictor of adiponectinlevels in Japanese young children. Journal of Pediatric Endocrinology&Metabolism, 23, 913-20, 2010

Nishihara M, Yamada M, Nozaki M, Nakahira K, Yanagihara I. Transcriptional regulation of the human establishment of cohesion 1 homolog 2 gene. Biochemical and Biophysical Research Communications, 393(1), 111-7, 2010

Namba F, Hasegawa T, Nakayama M, Hamanaka T, Yamashita T, Nakahira K, Kimoto A, Nozaki M, Nishihara M, Mimura K, Yamada M, Kitajima H, Suehara N, Yanagihara I.Placental features of chorioamnionitis colonized with Ureaplasma species in preterm delivery. Pediatric Research, 67(2), 166-72, 2010

橋本博、山根努、池口満徳、中平久美子、柳原格.「腸炎ビブリオが産生する耐熱性溶血毒TDHの構造と機能」.日本結晶学会誌、52、285-9、2010 

2009年

西原正泰、南 佐和子、八木重孝、米本直裕、柳原 格、樋口隆造.「和歌山県における後期死産の検討(2003-2007年)」.日本周産期・新生児医学会雑誌、45(4)、1350-3、2009

2008年

Hamada D, Tsumoto K, Sawara M, Tanaka N, Nakahira K, Shiraki K, Yanagihara I. Effect of amyloidogenic sequence attached to yellow fluorescent protein. Proteins, Aug 15, 2(3), 811-21, 2008

Hamaguchi M, Hamada D, Suzuki K, Sakata N,Yanagihara I.Molecular basis of actin reorganization promoted by binding of enterohaemorrhagicEscherichia coliEspB to alpha-Catenin.FEBS J, 0275(24), 6260-7, Dec,2008, Epub, Nov 7, 2008

柳原 格.「妊産婦及び早産児からのウレアプラズマ属細菌の分離培養」.日本産婦人科感染症研究会雑誌、224、41-5、2008

柳原 格、下谷浩一郎.「胎内感染と流早産・新生児合併症座長のまとめ」.日本周産期・新生児医学会会誌、44、1032-3、2008

難波文彦、北島博之、中山雅弘、藤村正哲、柳原 格.「子宮内感染/炎症と抗アネキシンA2 IgM抗体」.小児科、49(7)、989-94、2008

白石 淳、北島博之、藤村正哲、難波文彦、柳原 格、長谷川妙子、田端厚之、中山雅弘.「当センターにおける超早産児からのウレアプラズマ属細菌の検出頻度とその臨床背景」.近畿新生児研究会会誌、17、31-5、2008

野崎昌俊、柳原 格.「V(D)J組換え~accessibilityから病態解析まで~」.大阪府立母子保健総合医療センター雑誌、24(2)、65-70、2008

2007年

Agata Y, Tamaki N, Ikawa T, Masuda K, Sakamoto S, Kawamoto H, Murre C.Regulation of T Cell Receptor b Gene Rearrangements and Allelic Exclusion by the Helix-Loop-Helix Protein. E47, Immunity, 27, 871-84, 2007

Hayashi M, Hatsukawa Y, Yasui M, Yanagihara I, Ohguro H, Fujikado T. Cancer-associated retinopathy in a child with Langerhans cell histiocytosis.Jpn J Ophthalmol, Sep-Oct, 51(5), 393-6, 2007

Tanaka M, Yanagihara I, Takahashi H, Hamaguchi M, Nakahira K, Sakata I. The mRNA expression of fatty acid amide hydrolase in human whole blood correlates with sepsis. J Endotoxin Res, 13(1), 35-8, 2007

Namba F, Kitajima H. Utility of a new transcutaneous jaundice device with two optical paths in premature infants. PediatrInt49, 497-501, 2007

Hamada D, Higurashi T, Mayanagi K, Miyata T, Fukui T, Iida T, Honda T, Yanagihara I. Tetrameric structure of thermostable direct hemolysin from vibrio parahaemolyticus revealed by ultracentrifugation, small-angle X-ray scattering and electron microscopy. J MolBiol, Jan 5, 365(1), 187-95, 2007, EpubSep 29, 2006

2006年

Namba F, Kitajima H, Tabata A, Nakayama M, Suehara N, MatsunamiK,Yanagihara K, Nishihara M, Morita A, Yamada M, Kimoto A, Hirano S, SekiguchiK,Fujimura M, Yanagihara I. Anti-annexin A2 IgM antibody in preterm infants: its association with chorioamnionitis.Pediatr Res, Dec, 60(6), 699-704, 2006, EpubOct 25, 2006

Fujiyama K, Saejung W, Yanagihara I, Nakado J, Misaki R, Honda T, Watanabe Y, Seki T. In Planta production of immunogenic poliovirus peptide using tobacco mosaic virus-based vector system. J BiosciBioeng, May, 101(5), 398-402, 2006

Tabata A, Namba F, Yamada M, Hasegawa T, Nakahira K, Hamada D, Kitajima H, Fukusaki E, Yanagihara I. Expression and purification of recombinant human annexin A2 in Pichiapastoris and utility of expression product for detecting annexin A2 antibody. J BiosciBioeng, Feb, 101(2), 190-7, 2006

柳原 格.「周産期におけるプロバイオティクスの重要性」.日本未病システム学会、シンポジウムⅢ「プロバイオティクスと未病」1、12(1)、40-2、2006

山田 穣、柳原 格、西原正泰.「Roberts症候群の原因遺伝子ESCO2に関する研究」.大阪府立母子保健総合医療センター雑誌、22(2)、45-6、2006

2005年

Fukui T, Shiraki K, Hamada D, Hara K, Miyata T, Fujiwara S, Mayanagi K, Yanagihara K, Iida T, Fukusaki E, Imanaka T, Honda T, Yanagihara I. Thermostable direct hemolysin of Vibrio parahaemolyticus is a bacterial reversible amyloid toxin. Biochemistry, Jul, 26, 44(29), 9825-32, 2005

Kato T, Hamada D, Fukui T, Hayashi M, Honda T, Murooka Y, Yanagihara I. A pH-dependent conformational change in EspA, a component of the Escherichia coliO157, H7 type III secretion system.FEBS J, Jun, 272(11), 2773-83, 2005

Vega H, Waisfisz Q, Gordillo M, Sakai N, Yanagihara I, Yamada M, van Gosliga D, Kayserili H, Xu C, Ozono K, Jabs EW, Inui K, Joenje H. Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeastECO1 that is essential for the establishment of sister chromatid cohesion. Nat Genet. May, 37(5), 468-70,2005, Epub Apr 10, 2005

Shiraki K, Kudou M, Sakamoto R, Yanagihara I, Takagi M. Amino Acid esters prevent thermal inactivation and aggregation of lysozyme. BiotechnolProg, Mar-Apr, 21(2), 640-3, 2005

Hamada D, Kato T, Ikegami T, Suzuki KN, Hayashi M, Murooka Y, Honda T, Yanagihara I. EspB from enterohaemorrhagicEscherichia coli is a natively partially folded protein. FEBS J, Feb, 272(3), 756-68, 2005

西原正泰、柳原 格.「姉妹染色分体の接着異常と疾患」.大阪府立母子保健総合医療センター雑誌、21(2)、68-74、2005

田端厚之、長谷川妙子、柳原 格、稲岡千佳子、片山 徹、美濃孝美、藤原 太、中山雅弘、濱中拓郎、末原則幸、白石 淳、北島博之.「妊産婦及び早産児からのウレアプラズマ属細菌の分離培養法の確立」.大阪府立母子保健総合医療センター雑誌、21(1)、40-47、2005

2004年

Daizo Hamada, ItaruYanagihara,KouheiTsumoto. Engineering amyloidgenicity toward development of nanofibrillar materials. Trends in Biotechnology. 22, 93-97, 2004

Minoru Yamada, Koji Inui, Daizo Hamada, KumikoNakahira, Keiko Yanagihara, Norio Sakai, ToshinoriNishigaki, Keiichi Ozono, ItaruYanagihara. Analysis of recombinant human saposin A expressed by Pichiapastoris. Biochem,Biophys, Res,Commin, 318, 588-93, 2004

Tadato Ban, Masaru Hoshino, Satoshi Takahashi, Daizo Hamada, Kazuhito Hasegawa, Hironobu Naiki, Yuji Goto. Direct observation of Ab amyloid fibril growth and inhibition. J MolBiol, 344, 757-67, 2004

Kaori Kumazaki, Masahiro Nakayama, ItaruYanagihara, Noriyuki Suehara, Yoshinao Wada. Immunohistochemical distribution of Toll-like receptor 4 in term and preterm human placentas from normal and complicated pregnancy including chirioamnionitis. Human Pathology, 35, 1, 47-54, 2004

Kazuhiro Fujiyama, Yohei Sakai, Ryo Misaki, ItaruYangaihara, Takeshi Honda, Hiroyuki Anzai, Tatsuji Seki. N-linked glycan structures of human lactoferrin produced by transgenic Rice. BiosciBiotechnolBiochem, 12, 2565-70, 2004

Noriko Tsuda, ItaruYangaihara, Hitoshi Takahashi, Ikuhiro Sakata. Development of a simple method of detecting acetaminophen using 96 well microplate readers. The Japanese Journal of Toxicology. 17(3), 267-71, 2004

柳原恵子、真野利之、下野九理子、神尾範子、山田穣、柳原格、今井克美.「グルコーストランスポーター1(Glut-1)異常症 -ケトン食により本質的治療が可能なてんかんー」.臨床脳波、46、513-18、2004

柳原保武、柳原格.スピロヘータ感染症―梅毒、ライム病、レプトスピラ病「感染症と移植」、今日の移植、17、2、185-93、2004

柳原格.「ブルセラ症」.今日の治療指針2004年度版、146-47、2004

柳原格.「96ウェルマイクロプレートリーダーを用いたアセトアミノフェン簡易定量法の開発(2004)」.中毒研究、17:267-271、2004.

2003年

Tadato Ban, Daizo Hamada, Kazuhiro Hasegawa, Hironobu Naiki, Yuji Goto. Direct observation of amyloid fibril growth monitored by thioflavin T fluorescence. J BiolChem, 278, 16462-5, 2003

Lesley H. Greene, Daizo Hamada, Stephen J. Eyles, Keith Brew. Conserved signature proposed for folding in the lipocalin superfamily. FEBS Letters, 553, 39-44, 2003

Ryo Misaki, Hidekazu Nagaya, Kazuhito Fujiyama, ItaruYanagihara, Takeshi Honda, Tetsuji Seki. N-linked glycan structures of mouse interferon-beta produced by bombyxmori larvae, BBRC, 979-86, 2003

Imai Y, Fukui T, Kurohane K, Miyamoto D, Suzuki Y, Ishikawa T, Ono Y, Miyake M. Restricted expression of shiga toxin binding sites on mucosal epithelium of mouse distal colon.Infect Immun. Feb, 71(2), 985-90, 2003

浜田大三.「アミロイドー形成機構と新機材料としての可能性」.生物物、43(1)、4-8、2003

長谷川妙子、稲岡千佳子、片山 徹、美濃孝美、藤原 太、宮道 徹、中山雅弘、柳原 格.「黄色ブドウ球菌のプラスミドタイピング有用性について」.大阪府立母子保健総合医療センター雑誌、19(2)、38-41、2003

2002年

Cantarelli VV, Takahashi A, Yanagihara I, Akeda Y, Imura K, Kodama T, Kono G, Sato Y, Iida T, Honda T.Cortactin is necessary for F-actin accumulation in pedestal structures induced by enteropathogenic Escherichia coli infection. Infect Immun, 70(4), 2206-9, 2002

Hamada D, Dobson CM. A kinetic study of b-lactoglobulin amyloid fibril formation promoted by urea. Protein Sci, 11(10), 2417-26, 2002

Maeda M, Hamada D, Hoshino M,Onda Y, Hase T, Goto Y. Partially folded structure of flavin adenine dinucleotide-depleted ferredoxin-NADP+ reductase with residual NADP+ binding domain.J BiolChem, 277(19), 17101-7, 2002

Akagi M, Inui K, Tsukamoto H, Sakai N, Muramatsu T, Yamada M, Matsuzaki K, Goto Y, Nonaka I, Okada S. A point mutation of mitochondrial ATPase 6 gene in Leigh syndrome. Neuromuscul Dis, 12, 53-5, 2002

Muramatsu T, Sakai N, Yanagihara I, Yamada M, Nishigaki T, Kokubu C, Tsukamoto H, Ito M, Inui K.Mutational analysis of the acid ceramidasegenen in the Japanese patients with Farber lipogranulomatosis. J Inherit Metab Dis, 25, 585-92. 2002

Long-term response to zonisamide in patients with West syndrome.Suzuki Y, Imai K, Toribe Y, Ueda H, Yanagihara K, Shimono K, Okinaga T, Ono J, Nagai T, Matsuoka T, Tagawa T, Abe J, Morita Y, Fujikawa Y, Arai H, Mano T, Okada S. Neurology, 58, 1556-9, 2002

柳原保武、柳原格.「梅毒」.日本内科学雑誌(日本内科学会創立100周年記念号)、91(10)、2983-9、2002

柳原 格、濵田大三、柳原恵子.「腸管出血性大腸菌と宿主相互作用」.大阪府立母子保健総合医療センター雑誌、18(1)、7-11、2002