環境影響部門

業績

2019年

Kawai M, Kinoshita S, Yamazaki M, Yamamoto K, Rosen CJ, Shimba S, Ozono K, Michigami T. Intestinal clock system regulates skeletal homeostasis. JCI Insight. 2019 Feb 7, [E-pub ahead of print]

2018年

Yamamoto K, Kawai M, Yamazaki M, Tachikawa K, Kubota T, Ozono K, Michigami T. CREB activation in hypertrophic chondrocytes is involved in the skeletal overgrowth in epiphyseal chondrodysplasia Miura type caused by activating mutations of natriuretic peptide receptor B. Hum Mol Genet. 2018 Dec 13, [E-pub ahead of print]

Hasegawa Y, Kawai M, Bessho K, Yasuda K, Ueno T, Satomura Y, Konishi A, Kimura T, Ikeda K, Tachibana M, Miyoshi Y, Michigami T, Kondou H, Ozono K. CYP7A1 expression in hepatocytes is retained with upregulated fibroblast growth factor 19 in pediatric biliary atresia. Hepatol Res. 2018 Aug 29, [E-pub ahead of print]

Michigami T, Kawai M, Yamazaki M, Ozono K. Phosphate as a signaling molecule and its sensing mechanism. Physiol Rev. 98:2317–2348, 2018

Kubota T, Nakayama H, Kitaoka T, Nakamura Y, Fukumoto S, Fujiwara I, Hasegawa Y, Ihara K, Kitanaka S, Koyama S, Kusuda S, Mizuno H, Nagasaki K, Oba K, Sakamoto Y, Takubo N, Shimizu Y, Tanahashi Y, Hasegawa K, Tsukahara H, Yorifuji T, Michigami T, Ozono K. Incidence rate and characteristics of symptomatic vitamin D deficiency in children: a nationwide survey in Japan. Endocr J. 65:593–599, 2018

Akiyama T, Kubota T, Ozono K, Michigami T, Kobayashi D, Takeyari S, Sugiyama Y, Noda M, Harada D, Namba N, Suzuki A, Utoyama M, Kitanaka S, Uematsu M, Mitani Y, Matsunami K, Takishima S, Ogawa E, Kobayashi K. Pyridoxal 5-phosphate and related metabolites in hypophosphatasia: Effects of enzyme replacement therapy. Mol Genet Metab. 125:174–180, 2018

Oyachi M, Harada D, Sakamoto N, Ueyama K, Kondo K, Kishimoto K, Izui M, Nagamatsu Y, Kashiwagi H, Yamamuro M, Tamura M, Kikuchi S, Akiyama T, Michigami T, Seino Y, Namba N. A case of perinatal hypophosphatasia with a novel mutation in the ALPL gene: clinical course and review of the literature. Clin Pediatr Endocrinol. 27:179–186, 2018

Ikenoue S, Miyakoshi K, Ishii T, Sato Y, Otani T, Akiba Y, Kasuga Y, Ochiai D, Matsumoto T, Ichihashi Y, Matsuzaki Y, Tachikawa K, Michigami T, Nishimura G, Ikeda K, Hasegawa T, Tanaka M. Discordant fetal phenotype of hypophosphatasia in two siblings. Am J Med Genet A. 176:171–174, 2018

2017年

Watanabe R, Fujita N, Sato Y, Kobayashi T, Morita M, Oike T, Miyamoto K, Kuro-O M, Michigami T, Fukumoto S, Tsuji T, Toyama Y, Nakamura M, Matsumoto M, Miyamoto T. Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions. Sci Rep. 7:7886, 2017

Kitaoka T, Tajima T, Nagasaki K, Kikuchi T, Yamamoto K, Michigami T, Okada S, Fujiwara I, Kokaji M, Mochizuki H, Ogata T, Tatebayashi K, Watanabe A, Yatsuga S, Kubota T, Ozono K. Safety and efficacy of treatment with asfotase alfa in patients with hypophosphatasia: Results from a Japanese clinical trial. Clin Endocrinol (Oxf). 87:10–19, 2017

Nishino J, Yamazaki M, Kawai M, Tachikawa K, Yamamoto K, Miyagawa K, Kogo M, Ozono K, Michigami T. Extracellular phosphate induces the expression of dentin matrix protein 1 through the FGF receptor in osteoblasts. J Cell Biochem. 118:1151–1163, 2017

Yamamura-Miyazaki N, Yamamoto K, Fujiwara K, Santo Y, Michigami T, Kitajima H, Satomura K. Risk factors associated with a decreased estimated glomerular filtration rate based on cystatin C levels in school-age children with extremely low birthweight. Nephrology (Carlton). 22:463–469, 2017

Kajita S, Yamamoto T, Tsugawa N, Nakayama H, Kubota T, Michigami T, Ozono K. Serum calcitriol levels in a patient with X-linked hypophosphatemia complicated by autosomal dominant polycystic kidney disease. CEN Case Rep. 6:29–35, 2017

Okazaki R, Ozono K, Fukumoto S, Inoue D, Yamauchi M, Minagawa M, Michigami T, Takeuchi Y, Matsumoto T, Sugimoto T. Assessment criteria for vitamin D deficiency/insufficiency in Japan: proposal by an expert panel supported by the Research Program of Intractable Diseases, Ministry of Health, Labour and Welfare, Japan, the Japanese Society for Bone and Mineral Research and the Japan Endocrine Society [Opinion]. Endocr J. 64:1–6, 2017

Okazaki R, Ozono K, Fukumoto S, Inoue D, Yamauchi M, Minagawa M, Michigami T, Takeuchi Y, Matsumoto T, Sugimoto T. Assessment criteria for vitamin D deficiency/insufficiency in Japan: proposal by an expert panel supported by the Research Program of Intractable Diseases, Ministry of Health, Labour and Welfare, Japan, the Japanese Society for Bone and Mineral Research and the Japan Endocrine Society [Opinion]. J Bone Miner Metab. 35:1–5, 2017

2016年

Kawai M, Kinoshita S, Ozono K, Michigami T. Inorganic phosphate activates the AKT/mTORC pathway and shortens the life span of an a-Klotho-deficient model. J Am Soc Nephrol. 27:2810–2824, 2016

Ohata Y, Ozono K, Michigami T. Current concepts in perinatal mineral metabolism. Clin Pediatr Endocrinol. 25:9–17, 2016

Fujiwara M, Kubota T, Wang W, Ohata Y, Miura K, Kitaoka T, Okuzaki D, Namba N, Michigami T, Kitabatake Y, Ozono K. Successful induction of sclerostin in human derived fibroblasts by 4 transcription factors and its regulation by parathyroid hormone, hypoxia, and prostaglandin E2. Bone. 85:91–98, 2016

Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W. Global consensus recommendations on prevention and management of nutritional rickets. J Clin Endocrinol Metab. 101:394–415, 2016

Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W. Global consensus recommendations on prevention and management of nutritional rickets. Horm Res Paediatr. 85:83–106, 2016

Okazaki Y, Kitajima H, Mochizuki N, Kitaoka T, Michigami T, Ozono K. Lethal hypophosphatasia successfully treated with enzyme replacement from day 1 after birth. Eur J Pediatr. 175:433–437, 2016

2015年

Yamazaki M, Kawai M, Miyagawa K, Ohata Y, Tachikawa K, Kinoshita S, Nishino J, Ozono K, Michigami T. IL-1-induced acute bone resorption facilitates the secretion of fibroblast growth factor 23 into the circulation. J Bone Miner Metab, 33:342–354, 2015

Cundy T, Michigami T, Tachikawa K, Dray M, Collins JF, Raschalis EP, Gamsjaeger S, Roschger A. Reversible deterioration in hypophosphatasia caused by renal failure with bisphosphonate treatment. J Bone Miner Res. 30:1726–1732, 2015

Endo I, Fukumoto S, Ozono K, Namba N, Inoue D, Okazaki R, Yamauchi M, Sugimoto T, Minagawa M, Michigami T, Nagai M, Matsumoto T. Nationwide survey of fibroblast growth factor 23 (FGF23)-related hypophosphtaemic diseases in Japan: prevalemce, biochemical data and treatment. Endocr J. 62:811-816, 2015

Fukumoto S, Ozono K, Michigami T, Minagawa M, Okazaki R, Sugimoto T, Takeuchi Y, Matsumoto T. Pathogenesis and diagnostic criteria for rickets and osteomalacia-Proposal by an expert panel supported by Ministry of Health, Labour and Welfare, Japan. The Japanese Society for Bone and Mineral Ressearch and The Japan Endocrine Society. Endocr J.62:665-671, 2015

Fukumoto S, Ozono K, Michigami T, Minagawa M, Okazaki R, Sugimoto T, Takeuchi Y, Matsumoto T. Pathogenesis and diagnostic criteria for rickets and osteomalacia-Proposal by an expert panel supported by Ministry of Health, Labour and Welfare, Japan. The Japanese Society for Bone and Mineral Ressearch and The Japan Endocrine Society. J Bone Miner Metab.33:467-473, 2015

2014年

Miyagawa K, Yamazaki M, Kawai M, Nishino J, Koshimizu T, Ohata Y, Tachikawa K, Mikuni-Takagaki Y, Kogo M, Ozono K, Michigami T. Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice. PLoS One 9:e93840, 2014

Michigami T. Current understanding on the molecular basis of chondrogenesis. Clin Pediatr Endocrinol 23:1-8, 2014

Ohata Y, Yamazaki M, Kawai M, Tsugawa N, Tachikawa K, Koinuma T, Miyagawa K, Kimoto A, Nakayama M, Namba N, Yamamoto H, Okano T, Ozono K, Michigami T. Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of Hyp mice. J Bone Miner Res 29:1627-1638, 2014

Kawai M, Kinoshita S, Shimba S, Ozono K, Michigami T. Sympathetic activation induces skeletal Fgf23 expression in a circadian rhythm dependent manner. J Biol Chem, 289:1457-1466, 2014

Miura K, Kim OH, Lee HR, Namba N, Michigami T, Yoo WJ, Choi IH, Ozono K, Cho TJ. Overgrowth syndrome associated with a gain-of-function mutation of the natriuretic peptide receptor 2 (NPR2) gene. Am J Med Genet A. 164A:156-163, 2014

Matsushita M, Kitoh H, Michigami T, Tachikawa K, Ishiguro N. Benign prenatal hypophosphatasia: a treatable disease not to be missed. Pediatr Radiol 44:340-343, 2014

Takeyari S, Yamamoto T, Kinoshita Y, Fukumoto S, Glorieux FH, Michigami T, Hasegawa K, Kitaoka T, Kubota T, Imanishi Y, Shimotsuji T, Ozono K. Hypophosphatemic osteomalacaia and bone sclerosis caused by a novel homozygous mutation of the FAM20C gene in an elderly man with a mild variant of Raine syndrome. Bone. 67C:56-62, 2014

Kuroyanagi Y, Kawasaki H, Noda Y, Ohmachi T, Sekiya S, Yoshimura K, Ohe C, Michigami T, Ozono K, Kaneko K. A fetal case of infantile malignant osteopetrosis complicated by pulmonary arterial hypertention after hematopoietic stem cell transplantation. Tohoku J Exp Med. 234:309–312, 2014

2013年

Robinson JW, Dickey DM, Miura K, Michigami T, Ozono K, Potter LR. A human skeletal overgrowth mutation increases maximal velocity and blocks desensitization of guanylyl cyclase-B. Bone. 56:375-382, 2013

Michigami T. Regulatory mechanisms for the development of growth plate cartilage. Cell Mol Life Sci. 70:4213-4221, 2013

Michigami T. Extracellular phosphate as a signaling molecule. Contrib Nephrol. 180:14-24, 2013

Kondou H, Kawai M, Tachikawa K, Kimoto A, Yamagata M, Koinuma T, Yamazaki M, Nakayama M, Mushiake S, Ozono K, Michigami T. Sodium-coupled neutral amino acid transporter 4 functions as a regulator of protein synthesis during liver development. Hepatol Res. 43:4213-4221, 2013

Wada K, Harada D, Michigami T, Tachikawa K, Nakano Y, Kashiwagi H, Yamashita S, Sano T, Seino Y. A case of autosomal dominant osteopetrosis type II with a novel TCIRG1 gene mutation. J Pediatr Endocrinol Metab. 26:575-577, 2013

Matsui I, Hamano T, Mikami S, Inoue K, Shimomura A, Nagasawa Y, Michigami T, Ohnishi T, Fujii N, Nakano C, Kusunoki Y, Kitamura H, Iwatani H, Takabatake Y, Kaimori JY, Matsuba G, Okoshi K, Kimura-Suda H, Tsubakihara Y, Rakugi H, Isaka Y. Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats. Am J Physiol Renal Physiol. 304:F751-60, 2013

Kawai M, Kinoshita S, Kimoto A, Hasegawa Y, Miyagawa K, Yamazaki M, Ohata Y, Ozono K, Michigami T. FGF23 suppresses chondrocyte proliferation in the presence of soluble α-Klotho both in vivo and in vitro. J Biol Chem. 288:2414-2427, 2013

2012年

Haraikawa M, Tanabe R, Sogabe N, Sugimoto A, Kawamura Y, Michigami T, Hosoi T, Goseki-Sone M. A study of the association between serum bone-specific alkaline phosphatase and serum phosphorus concentration or dietary phosphorus intake. J Nutr Sci Vitaminol (Tokyo). 58:442-445, 2012

Ozono K, Namba N, Kubota T, Kitaoka T, Miura K, Ohata Y, Fujiwara M, Miyoshi Y, Michigami T. Pediatric aspects of skeletal dysplasia. Pediatr Endocrinol Rev. 10 Suppl 1:35-43, 2012

Miura K, Namba N, Fujiwara M, Ohata Y, Ishida H, Kitaoka T, Kubota T, Hirai H, Higuchi C, Tsumaki N, Yoshikawa H, Sakai N, Michigami T, Ozono K. An overgrowth disorder associated with excessive production of cGMP due to a gain-of-function mutation of the natriuretic peptide receptor 2 gene. PLoS One. 7:e42180, 2012

Onodera A, Tani M, Michigami T, Yamagata M, Min KS, Tanaka K, Nakanishi T, Kimura T, Itoh N. Role of megalin and the soluble form of its ligand RAP in Cd-metallothionein endocytosis and Cd-metallothionein-induced nephrotoxicity in vivo. Toxicol Lett. 212: 91-96, 2012

Koshimizu T, Kawai M, Kondou H, Tachikawa K, Sakai N, Ozono K, Michigami T. Vinculin functions as regulator of chondrogenesis. J Biol Chem. 287:15760-15775, 2012

2011年

Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T, Imura A, Nabeshima YI, Yamazaki Y, Ozono K. Circulating levels of soluble α-Klotho are markedly elevated in human umbilical cord blood. J Clin Endocrinol Metab. 96:E943-947, 2011

Kawai M, Breggia AC, Demambro VE, Shen X, Canalis E, Bouxsein ML, Beamer WG, Clemmons DR, Rosen CJ. The Heparin-binding domain of IGFBP-2 has insulin-like growth factor binding-independent biologic activity in the growing skeleton. J Biol Chem. 286:14670-14680, 2011

Ozono K, Michigami T. Hypophosphatasia now draws more attention of both clinicians and researchers: a commentary on Prevalence of c.1559delT in ALPL, a common mutation resulting in the perinatal (lethal) form of hypophosphatasias in Japanese and effects of the mutation on heterozygous carriers. J Hum Genet. 56:174-176, 2011

Kawai M, Modder U, Khosla S, Rosen CJ. Emerging therapeutic opportunities for skeletal restoration. Nat Rev Drug Discov. 10:141-156, 2011s

Sugita A, Kawai S, Hayashibara T, Amano A, Ooshima T, Michigami T, Yoshikawa H, Yoneda T. Cellular ATP synthesis mediated by type III sodium-dependent phosphate transporter Pit-1 is critical to chondrogenesis. J Biol Chem. 286:3094-3103, 2011

2010年

Yamazaki M, Ozono K, Okada T, Tachikawa K, Kondou H, Ohata Y, Michigami T. Both FGF23 and extracellular phosphate activate Raf/MEK/ERK pathway via FGF receptors in HEK293 cells. J Cell Biochem. 111:1210-1221, 2010

Kimata M, Michigami T*, Tachikawa K, Okada T, Koshimizu T, Yamazaki M, Kogo M, Ozono K. Signaling of inorganic extracellular phosphate up-regulates cyclin D1 expression in proliferating chondrocytes via the type III Na+/Pi cotransporter Pit-1 and Raf/MEK/ERK pathway. Bone. 47:938-947,2010 (*Corresponding author)

Kubota T, Michigami T, Ozono K. Wnt signaling in bone. Clin Pediatr Endocrinol. 19:49-56, 2010

Nakamura-Utsunomiya A, Okada S, Hara K, Miyagawa S, Takeda K, Fukuhara R, Nakata Y, Hayashidani M, Tachikawa K, Michigami T, Ozono K, Kobayashi M. Clinical characteristics of perinatal lethal hypophosphatasia: A report of 6 cases. Clin Pediatr Endocrinol. 19:7-13, 2010

2009年

Ohata Y, Yamamoto T, Mori I, Kikuchi T, Michigami T, Imanishi Y, Satomura K, Ida S, Ozono K. Severe arterial hypertension: a possible complication of McCune-Albright syndrome. Eur J Pediatr. 168:871-876, 2009

Matsui Y, Michigami T, Tachikawa K, Yamazaki M, Kawabata H, Nishimura G. Czech dysplasia occurring in a Japanese family. Am J Med Genet(A). 149A:2285-2289, 2009

Kubota T, Michigami T, Ozono K. Wnt signaling in bone metabolism. J Bone Miner Metab. 27:265-271, 2009

Miyauchi Y, Sakaguchi N, Okada T, Makishima M, Ozono K, Michigami T. Oncogenic nucleoporin CAN/Nup214 interacts with vitamin D receptor and modulates its function. J Cell Biochem. 106:1090-1101, 2009

2008年

Fukumoto S, Namba N, Ozono K, Yamauchi M, Sugimoto T, Michigami T, Tanaka H, Inoue D, Minagawa M, Endo I, Matsumoto T. Causes and differential diagnosis of hypocalcemia-recommendation proposed by expert panel supported by ministry of health, labour and welfare, Japan-. Endocr J. 55:787-794, 2008

Kubota T, Michigami T, Sakaguchi N, Kokubu C, Suzuki A, Namba N, Sakai N, Nakajima S, Imai K, Ozono K. Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd. J Bone Miner Res. 23:1661-1671, 2008

Endo I, Fukumoto S, Ozono K, Namba N, Tanaka H, Inoue D, Minagawa M, Sugimoto T, Yamauchi M, Michigami T, Matsumoto T. Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients. Proposal of diagnostic criteria using FGF23 measurement. Bone. 42:1235-1239, 2008

Suzuki A, Ozono K, Kubota T, Kondou H, Tachikawa K, Michigami T. PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3β in osteoblastic Saos-2 cells. J Cell Biochem. 104:304-317, 2008

2007年

Kawai M, Mushiake S, Bessho K, Murakami M, Kokubu C, Michigami T, Ozono K. Wnt/Lrp/β-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARγ and C/EBPα. Biochem Biophys Res Commun. 363:276-282, 2007

Uchihashi T, Kimata M, Tachikawa K, Koshimizu T, Okada T, Ihara-Watanabe M, Sakai N, Kogo M, Ozono K, Michigami T. Involvement of nuclear factor I transcription/replication factor in the early stage of chondrocytic differentiation. Bone.41:1025-1035, 2007

Yamamoto T, Michigami T, Aranami F, Segawa H, Yoh K, Nakajima S, Miyamoto KI, Ozono K. Hereditary hypophosphatemic rickets with hypercalciuria: a study for the phosphate transporter gene IIc and osteoblastic function. J Bone Miner Metab. 25:407-413, 2007

2006年

Ozono K, Michigami T, Namba N, Nakajima S, Yamamoto T. Molecular bases of diseases characterized by hypophosphatemia and phosphaturia: New understanding. Clin Pediatr Endocrinol. 15:129-135, 2006

Yamazaki M, Suzuki A, Ozono K, Michigami T. G-protein stimulatory alpha subunit is involved in osteogenic activity in osteoblastic cell line SaOS-2 cells. Clin Pediatr Endocrinol. 15:65-72, 2006

Miyoshi Y, Santo Y, Tachikawa K, Namba N, Hirai H, Mushiake S, Nakajima S, Michigami T, Ozono K. Lack of puberty despite elevated estradiol in a 46,XY phenotypic female with Frasier symdrome. Endocr J. 53:371-376, 2006

Goto T, Matsui Y, Fernandes RJ, Hanson DA, KuboT, Yukata K, Michigami T, Komori T, Fujita T, Yang L, Eyre DR, Yasui N. Sp1 family of transcription factors regulates the human α2(XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. J Bone Miner Res. 21:661-673, 2006

2005年

Miyauchi Y, Michigami T*, Sakaguchi N, Sekimoto T, Yoneda Y, Pike JW, Yamagata M, Ozono K. Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor. J Biol Chem. 280:40901-40908, 2005 (*corresponding author)

Yamagata M, Ozono K, Hashimoto Y, Miyauchi Y, Kondou H, Michigami T. Intraperitoneal administration of recombinant receptor-associated protein causes phosphaturia via an alteration in subcellular distribution of the renal sodium phosphate co-transporter. J Am Soc Nephrol. 16:2338-2345, 2005

Michigami T, Uchihashi T, Suzuki A, Tachikawa K, Nakajima S, Ozono K. Common mutations F310L and T1559del in tissue-nonspecific alkaline phosophatase gene are related to distinct phenotype in Japanese patients with hypophosphatasia. Eur J Pediatr. 164:277-282, 2005

Ozono K, Nakajima S, Michigami T. Vitamin D and reproductive organs. In: Feldman D, Pike JW, Glorieux FH (eds) Vitamin D, 2nd Edition. Elsevier Academic Press, Burlington, pp851-861, 2005

2004年

Ihara-Watanabe M, Uchihashi T, Miyauchi Y, Sakai N, Yamagata M, Ozono K, Michigami T. Involvement of phosphoinositide 3-kinase signaling pathway in chondrocytic differentiation of ATDC5 cells: application of a gene-trap mutagenesis. J Cell Biochem. 93:418-426, 2004

Santo Y, Hirai H, Shima M, Yamagata M, Michigami T, Nakajima S, Ozono K. Examination of megalin in renal tubular epithelium from patients with Dent disease. Pediatr Nephrol. 19:612-615, 2004

2003年

Kondou H, Mushiake S, Etani Y, Miyoshi Y, Michigami T, Ozono K. A blocking peptide for transforming growth factor-β1 activation prevents hepatic fibrosis in vivo.J Hepatol. 39:742-748, 2003

Myoui A, Nishimura R, Williams PJ, Hiraga T, Tamura D, Michigami T, Mundy GR, Yoneda T. C-Src tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis. Cancer Res. 63:5028-5033, 2003

2002年

Michigami T, Kageyama T, Satomura K, Shima M, Yamaoka K, Nakayama M, Ozono K. Novel mutations in the a3 subunit of vacuolar H+-adenosine triphosphatase in a Japanese patient with infantile malignant osteopetrosis. Bone. 30:436-439, 2002

Michigami T, Hiraga T, Williams PJ, Niewolna M, Nishimura R, Mundy GR, Yoneda T. The effect of the bisphosphonate ibandronate on breast cancer metastasis to visceral organs. Breast Cancer Res Treat. 75:249-258, 2002

2001年

Yamamoto T, Miyamoto K, Ozono K, Taketani Y, Katai K, Miyauchi A, Shima M, Yoshikawa H, Yoh K, Takeda E, Okada S. Hypophosphatemic rickets accompanying McCune-Albright syndrome: evidence that a humoral factor causes hypophosphatemia. J Bone Miner Metab. 19:287-295, 2001

Michigami T, Yamato H, Suzuki H, Nagai-Itagaki Y, Sato K, Ozono K. Conflicting actions of parathyroid hormone-related protein and serum calcium as regulators of 25-hydroxyvitamin D3-1α-hydroxylase expression in a nude rat model of humoral hypercalcemia of malignancy. J Endocrinol. 171:249-251, 2001

Yamagata M, Kimoto A, Michigami T, Nakayama M, Ozono K. Hydroxylases involved in vitamin D metabolism are differentially expressed in murine embryonic kidney: Application of whole mount in situ hybridization. Endocrinology. 142:3223-3230, 2001

Michigami T, Ihara-Watanabe M, Yamazaki M, Ozono K. Receptor activator of NF-κB ligand (RANKL) is a key molecule of osteoclast formation for bone metastasis in a newly- developed model of human neuroblastoma. Cancer Res. 61:1637-1644, 2001

Hirai H, Nakajima S, Miyauchi A, Nishimura K, Shimizu N, Shima M, Michigami T, Ozono K, Okada S. A novel activating mutation in calcium-sensing receptor gene (C129S) in a Japanese family with autosomal dominant hypocalcemia. J Hum Genet. 46:41-44, 2001

2000年

Michigami T, Shimizu N, Williams PJ, Niewolna M, Dallas SL, Mundy GR, Yoneda T. Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha4beta1-integrin enhances production of osteoclast-stimulating activity. Blood. 96:1953-1960, 2000

Mochizuki H, Saito M, Michigami T, Ohashi H, Koda N, Yamaguchi S, Ozono K. Severe hypercalcemia and respiratory insufficiency associated with infantile hypophosphatasia caused by two novel mutations of the TNSALP gene. Eur J Pediatr. 159:375-379, 2000

Muller HL, Yamazaki M, Michigami T, Kageyama T, Schonau E, Schneider P, Ozono K. Asp361Val mutant of alkaline phosphatase found in patients with dominantly inherited hypophosphatasia inhibits the activity of the wild-type enzyme. J Clin Endocrinol Metab. 85:743-747, 2000

Yanagihara I, Yamagata M, Sakai N, Shukunami C, Kurahashi H, Yamazaki M, Michigami T, Hiraki Y, Ozono K. Genomic organization of the human chondromodulin-1 gene containing a promoter region which confers the expression of reporter gene in chondrogenic ATDC5 cells. J Bone Miner Res. 15:421-429, 2000

1999年

Michigami T, Suga A, Yamazaki M, Shimizu C, Cai G, Okada S, Ozono K. Identification of amino acid sequence in the hinge region of human vitamin D receptor which transfers a cytosolic protein to the nucleus. J Biol Chem. 274: 33531-33538, 1999

Ozono K, Saito M, Miura D, Michigami T, Nakajima S, Ishizuka S. Analysis of the molecular mechanism for the antagonistic action of a novel 1α,25-dihydroxyvitamin D3 analogue toward vitamin D receptor function. J Biol Chem. 274:32376-32381, 1999

Yoneda T, Michigami T, Yi B, Williams PJ, Niewolna M, Hiraga T. Use of bisphosphonates for the treatment of bone metastasis in experimental animal models. Cancer Treat Rev. 25:293-299, 1999

1998年

Michigami T, Nomizu M, Yamada Y, Dunstan C, Williams PJ, Mundy GR, Yoneda T. Growth and dissemination of a newly-established murine B-cell lymphoma cell line is inhibited by multimeric YIGSR peptide. Clin Exp Metastasis. 16:645-654, 1998

Cai G, Michigami T, Yamamoto T, Yasui N, Satomura K, Yamagata M, Shima M, Nakajima S, Mushiake S, Okada S, Ozono K. Analysis of localization of mutated tissue-nonspecific alkaline phosphatase proteins associated with neonatal hypophosphatasia using green fluorescent protein chimeras. J Clin Endocrinol Metab. 83:3936-3942, 1998

1996年

Ozono K, Yamagata M, Michigami T, Nakajima S, Sakai N, Cai G, Satomura K, Yasui N, Okada S, Nakayama M. Identification of novel mutations (Phe310Leu and Gly439Arg) in a neonatal case of hypophosphatasia. J Clin Endocrinol Metab. 81:4458-4461, 1996

Michigami T, Yamato H, Mushiake S, Nakayama M, Yoneda A, Satomura K, Imura K, Ozono K. Hypercalcemia associated with infantile fibrosarcoma producing parathyroid hormone-related protein. J Clin Endocrinol Metab. 81:1090-1095, 1996

Yamamoto T, Ozono K, Kasayama S, Yoh K, Hiroshima K, Takagi M, Matsumoto S, Michigami T, Yamamoto K, Kishimoto T, Okada S. Increased IL-6 production by cells isolated from the fibrous bone dysplasia tissues in patients with McCune-Albright syndrome. J Clin Invest. 98:30-35, 1996