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分子遺伝・内分泌代謝研究部門

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2024年

  1. Kawai M, Baba S, Tanigawa K, Ikehara S, Kawasaki R, Iso H. Association of nighttime sleep duration at 1.5 years with height at 3 years: The Japan Environment and Children's Study. J Clin Endocrinol Metab. 2024.
  2. Onuma S, Kawai M*. Circadian Regulatory Networks of Glucose Homeostasis and Its Disruption as a Potential Cause of Undernutrition. Endocrinology. 2024;165(11).
  3. Juul A, Backeljauw P, Hojby M, Frystyk J, Kawai M, Kildemoes RJ, Lemminger AK, Linglart A, Zuckerman-Levin N, Horikawa R. Somapacitan in Children Born SGA: 52-week Efficacy, Safety, and IGF-I Response Results from the Phase 2 REAL5 Study. J Clin Endocrinol Metab. 2024.
  4. Shoji Y, Hata A, Maeyama T, Wada T, Hasegawa Y, Nishi E, Ida S, Etani Y, Niihori T, Aoki Y, Okamoto N, Kawai M*. Genetic backgrounds and genotype-phenotype relationships in anthropometric parameters of 116 Japanese individuals with Noonan syndrome. Clin Pediatr Endocrinol. 2024;33(2):50-58.
  5. Kimizu T, Nozaki M, Okada Y, Sawada A, Morisaki M, Fujita H, Irie A, Matsuda K, Hasegawa Y, Nishi E, Okamoto N, Kawai M, Imai K, Suzuki Y, Wada K, Mitsuda N, Ida S. Multiplex Real-Time PCR-Based Newborn Screening for Severe Primary Immunodeficiency and Spinal Muscular Atrophy in Osaka, Japan: Our Results after 3 Years. Genes (Basel). 2024;15(3).
  6. Ikegawa K, Koga E, Itonaga T, Sakakibara H, Kawai M, Hasegawa Y. Factors associated with low bone mineral density in Turner syndrome: a multicenter prospective observational study. Endocr J. 2024;71(6):561-569.
  7. Nakanishi T, Yamazaki M, Tachikawa K, Ueta A, Kawai M, Ozono K, Michigami T. Complex intrinsic abnormalities in osteoblast lineage cells of X-linked hypophosphatemia: Analysis of human iPS cell models generated by CRISPR/Cas9-mediated gene ablation. Bone. 2024;181:117044.
  8. Gravholt CH, Andersen NH, Christin-Maitre S, Davis SM, Duijnhouwer A, Gawlik A, Maciel-Guerra AT, Gutmark-Little I, Fleischer K, Hong D, Klein KO, Prakash SK, Shankar RK, Sandberg DE, Sas TCJ, Skakkebaek A, Stochholm K, van der Velden JA, International Turner Syndrome Consensus G, Backeljauw PF. Clinical practice guidelines for the care of girls and women with Turner syndrome. Eur J Endocrinol. 2024;190(6):G53-G151.
*: corresponding author

2023年

  1. Wada T, Mitani-Konno M, Tanase-Nakao K, Etani Y, Narumi S, Hasegawa Y, Kawai M*. Graves' disease as an emerging complication of MIRAGE syndrome. Pediatr Int. 2023;65(1):e15678.
  2. Kawai M*, Muroya K, Murakami N, Ihara H, Takahashi Y, Horikawa R, Ogata T. A questionnaire-based survey of medical conditions in adults with Prader-Willi syndrome in Japan: implications for transitional care. Endocr J. 2023;70(5):519-528.
  3. Konishi A, Koizumi M, Etani Y, Ida S, Kawai M*. Very young children with Prader-Willi syndrome are refractory to growth hormone-associated decreases in free thyroxine levels. Endocr J. 2023;70(5):501-509.
  4. Juul A, Backeljauw P, Hojby M, Kawai M, Kildemoes RJ, Linglart A, Zuckerman-Levin N, Horikawa R. Somapacitan in children born small for gestational age: a multi-centre, open-label, controlled phase 2 study. Eur J Endocrinol. 2023;188(1).
  5. Koizumi M, Ida S, Etani Y, Kawai M*. Reductions in estimated glomerular filtration rate during puberty in GH-treated children born small for gestational age are associated with prematurity and low birth weight, not the dosage of GH treatment. Clin Pediatr Endocrinol. 2023;32(2):98-104.
  6. Wada T, Nishigaki S, Hata A, Maeyama T, Ida S, Etani Y, Kawai M:. Dosage of hydrocortisone during late infancy is positively associated with changes in body mass index during early childhood in patients with 21-hydroxylase deficiency. Endocr J. 2023;70(3):333-340.
  7. Koizumi M, Ida S, Etani Y, Kawai M*. Evaluations for Wilms tumor and late-onset nephrotic syndrome in 46,XY DSD. Pediatr Int. 2023;65(1):e15418.
  8. Hasegawa Y, Hasegawa T, Satoh M, Ikegawa K, Itonaga T, Mitani-Konno M, Kawai M*. Pubertal induction in Turner syndrome without gonadal function: A possibility of earlier, lower-dose estrogen therapy. Front Endocrinol (Lausanne). 2023;14:1051695.
  9. Umeda S, Takase K, Takayama K, Yamamichi T, Higuchi K, Kawai M, Takeuchi M, Inoue M, Usui N. A Report of a Case With Pediatric Ovarian Steroid Cell Tumor, Not Otherwise Specified, Found With Precocious Puberty. J Pediatr Hematol Oncol. 2023;45(4):e522-e524.
*: corresponding author

2022年

  1. Onuma S, Kinoshita S, Shimba S, Ozono K, Michigami T, Kawai M*. The Lack of Bmal1, a Core Clock Gene, in the Intestine Decreases Glucose Absorption in Mice. Endocrinology. 2022;163(9).
  2. Koizumi M, Konishi A, Etani Y, Ida S, Kawai M*. Circulating insulin-like growth factor 1 levels are reduced in very young children with Prader-Willi syndrome independent of anthropometric parameters and nutritional status. Clin Endocrinol (Oxf). 2022;96(3):346-352.
  3. Kawai M*, Etani Y, Ida S. Subcutaneous adipose tissue is a positive predictor for bone mineral density in prepubertal children with Prader-Willi syndrome independent of lean mass. J Pediatr Endocrinol Metab. 2022;35(5):603-609.
  4. Wada T, Ichikawa C, Takeuchi M, Matsui F, Matsumoto F, Ida S, Etani Y, Kawai M*. Histological analysis of testes in patients with 5 alpha-reductase deficiency type 2: Comparison with cryptorchid testes in patients without endocrinological abnormalities and a review of the literature. Clin Pediatr Endocrinol. 2022;31(3):144-151.
  5. Michigami T, Tachikawa K, Yamazaki M, Nakanishi T, Kawai M, Ozono K. Growth-related skeletal changes and alterations in phosphate metabolism. Bone. 2022;161:116430.
  6. Maeyama T, Ichikawa C, Okada Y, Sawada A, Inoue M, Takeuchi M, Soh H, Usui N, Etani Y, Kawai M*. Beta-human chorionic gonadotropin-producing neuroblastoma: an unrecognized cause of gonadotropin-independent precocious puberty. Endocr J. 2022;69(3):313-318.
  7. Kawai M*. Disruption of the circadian rhythms and its relationship with pediatric obesity. Pediatr Int. 2022;64(1):e14992.
*: corresponding author

2021年

    1. Tanase-Nakao K, Kawai M, Wada K, Kagami M, Narumi S. Acquired uniparental disomy of chromosome 7 in a patient with MIRAGE syndrome that veiled a pathogenic SAMD9 variant. Clin Pediatr Endocrinol. 2021;30(4):163-169.
    2. Shoji Y, Ida S, Kubo T, Etani Y, Kawai M*. Diagnostic Pitfall: Mosaic Turner syndrome with a 46, XY lymphocyte karyotype. Pediatr Int. 2021;63(9):1122-1123.
    3. Nishigaki S, Itonaga T, Hasegawa Y, Kawai M*. Starting age of oestrogen-progestin therapy is negatively associated with bone mineral density in young adults with Turner syndrome independent of age and body mass index. Clin Endocrinol (Oxf). 2021;95(1):84-91.
    4. Konishi A, Ida S, Shoji Y, Etani Y, Kawai M*. Central hypothyroidism improves with age in very young children with Prader-Willi syndrome. Clin Endocrinol (Oxf). 2021;94(3):384-391.
    5. Koizumi M, Ida S, Shoji Y, Etani Y, Kawai M*. Renal function in short-statured children born small for gestational age and treated with growth hormone. Pediatr Int. 2021;63(7):775-781.
    6. Yamazaki M, Kawai M, Kinoshita S, Tachikawa K, Nakanishi T, Ozono K, Michigami T. Clonal osteoblastic cell lines with CRISPR/Cas9-mediated ablation of Pit1 or Pit2 show enhanced mineralization despite reduced osteogenic gene expression. Bone. 2021;151:116036.
    7. Maeyama T, Etani Y, Nishigaki S, Kawai M*. Nephrogenic diabetes insipidus caused by a novel missense variant (p.S127Y) in the AVPR2 gene. Clin Pediatr Endocrinol. 2021;30(2):115-118.
    8. Konishi A, Ida S, Matsui F, Etani Y, Kawai M*. Male assignment in 5alpha-reductase type 2 deficiency with female external genitalia. Pediatr Int. 2021;63(5):592-594.
    9. Hizuka K, Hagiwara SI, Maeyama T, Honma H, Kawai M, Akagi K, Yasuhara M, Tomita N, Etani Y. Constitutional mismatch repair deficiency in childhood colorectal cancer harboring a de novo variant in the MSH6 gene: a case report. BMC Gastroenterol. 2021;21(1):60.
    10. Kubo H, Kozan H, Kawai M. Ultrasonography for inguinal hernia led to the diagnosis of complete androgen insensitivity syndrome. Pediatr Int. 2021;63(1):122-123.
    11. Onuma S, Ida S, Maeyama T, Shoji Y, Etani Y, Kawai M*. Growth hormone treatment for extremely low birthweight children born small for gestational age. Pediatr Int. 2021;63(1):46-52.
*: corresponding author

2020年

  1. Onuma S, Wada T, Araki R, Wada K, Tanase-Nakao K, Narumi S, Fukui M, Shoji Y, Etani Y, Ida S, Kawai M*. MIRAGE syndrome caused by a novel missense variant (p.Ala1479Ser) in the SAMD9 gene. Hum Genome Var. 2020;7:4.
  2. Maeyama T, Ida S, Onuma S, Shoji Y, Yamamoto T, Etani Y, Kawai M*. Fat distribution in short-stature children born small for gestational age. Pediatr Int. 2020;62(12):1351-1356.
  3. Koizumi M, Ida S, Shoji Y, Nishimoto Y, Etani Y, Kawai M*. Visceral adipose tissue resides within the reference range in children with Prader-Willi syndrome receiving nutritional intervention on a regular basis. Endocr J. 2020;67(10):1029-1037.
  4. Kawai M*, Kinoshita S, Ozono K, Michigami T. Lack of PTEN in osteocytes increases circulating phosphate concentrations by decreasing intact fibroblast growth factor 23 levels. Sci Rep. 2020;10(1):21501.
  5. Itonaga T, Koga E, Nishigaki S, Kawai M, Sakakibara H, Hasegawa Y. A retrospective multicenter study of bone mineral density in adolescents and adults with Turner syndrome in Japan. Endocr J. 2020;67(10):1023-1028.
  6. Miyoshi Y, Yorifuji T, Shimizu C, Nagasaki K, Kawai M, Ishiguro H, Okada S, Kanno J, Takubo N, Muroya K, Ito J, Horikawa R, Yokoya S, Ozono K. A nationwide questionnaire survey targeting Japanese pediatric endocrinologists regarding transitional care in childhood, adolescent, and young adult cancer survivors. Clin Pediatr Endocrinol. 2020;29(2):55-62.
  7. Mizuno K, Shimizu T, Ida S, Ito S, Inokuchi M, Ohura T, Okumura A, Kawai M, Kikuchi T, Sakurai M, Sugihara S, Suzuki M, Takitani K, Tanaka D, Mushiake S, Yoshiike N, Kodama H, Okada K, Tsutsumi C, Hara M, Hanawa Y, Kawakami K, Inomata H, Oguni T, Bito Y, Uchida K, Sugiyama A. Policy statement of enteral nutrition for preterm and very low birthweight infants. Pediatr Int. 2020;62(2):124-127.
  8. Michigami T, Tachikawa K, Yamazaki M, Kawai M, Kubota T, Ozono K. Hypophosphatasia in Japan: ALPL Mutation Analysis in 98 Unrelated Patients. Calcif Tissue Int. 2020;106(3):221-231.
  9. Hasegawa Y, Itonaga T, Ikegawa K, Nishigaki S, Kawai M, Koga E, Sakakibara H, Ross JL. Ultra-low-dose estrogen therapy for female hypogonadism. Clin Pediatr Endocrinol. 2020;29(2):49-53.
*: corresponding author

2019年

  1. Shoji Y, Ida S, Niihori T, Aoki Y, Okamoto N, Etani Y, Kawai M*. Genotype-phenotype correlation analysis in Japanese patients with Noonan syndrome. Endocr J. 2019;66(11):983-994.
  2. Yamamoto K, Kawai M, Yamazaki M, Tachikawa K, Kubota T, Ozono K, Michigami T. CREB activation in hypertrophic chondrocytes is involved in the skeletal overgrowth in epiphyseal chondrodysplasia Miura type caused by activating mutations of natriuretic peptide receptor B. Hum Mol Genet. 2019;28(7):1183-1198.
  3. Kawai M*, Kinoshita S, Yamazaki M, Yamamoto K, Rosen CJ, Shimba S, Ozono K, Michigami T. Intestinal clock system regulates skeletal homeostasis. JCI Insight. 2019;4(5).
  4. Hasegawa Y, Kawai M, Bessho K, Yasuda K, Ueno T, Satomura Y, Konishi A, Kimura T, Ikeda K, Tachibana M, Miyoshi Y, Michigami T, Kondou H, Ozono K. CYP7A1 expression in hepatocytes is retained with upregulated fibroblast growth factor 19 in pediatric biliary atresia. Hepatol Res. 2019;49(3):314-323.
  5. Kawai M*. For Debate: When is Selenium Deficiency Suspected and When is Its Measurement Indicated? Pediatr Endocrinol Rev. 2019;16(3):307-310.
*: corresponding author

2018年

  1. Kawai M*, Shoji Y, Onuma S, Etani Y, Ida S. Thyroid hormone status in patients with severe selenium deficiency. Clin Pediatr Endocrinol. 2018;27(2):67-74.
  2. Koizumi M, Ida S, Shoji Y, Nishimoto Y, Etani Y, Kawai M*. Visceral adipose tissue increases shortly after the cessation of GH therapy in adults with Prader-Willi syndrome. Endocr J. 2018;65(11):1127-1137.
  3. Michigami T, Kawai M, Yamazaki M, Ozono K. Phosphate as a Signaling Molecule and Its Sensing Mechanism. Physiol Rev. 2018;98(4):2317-2348.
*: corresponding author

2017年

  1. Nishino J, Yamazaki M, Kawai M, Tachikawa K, Yamamoto K, Miyagawa K, Kogo M, Ozono K, Michigami T. Extracellular Phosphate Induces the Expression of Dentin Matrix Protein 1 Through the FGF Receptor in Osteoblasts. J Cell Biochem. 2017;118(5):1151-1163.

2016年

  1. Kawai M*, Kinoshita S, Ozono K, Michigami T. Inorganic Phosphate Activates the AKT/mTORC1 Pathway and Shortens the Life Span of an alpha‑Klotho-Deficient Model. J Am Soc Nephrol. 2016;27(9):2810-2824.
  2. Kawai M*. The FGF23/Klotho axis in the regulation of mineral and metabolic homeostasis. Horm Mol Biol Clin Investig. 2016;28(1):55-67.
  3. Kinoshita S, Kawai M*. The FGF23/KLOTHO Regulatory Network and Its Roles in Human Disorders. Vitam Horm. 2016;101:151-174.
*: corresponding author

2015年

  1. Yamazaki M, Kawai M, Miyagawa K, Ohata Y, Tachikawa K, Kinoshita S, Nishino J, Ozono K, Michigami T. Interleukin-1-induced acute bone resorption facilitates the secretion of fibroblast growth factor 23 into the circulation. J Bone Miner Metab. 2015;33(3):342-354.

2014年

  1. Miyagawa K, Yamazaki M, Kawai M, Nishino J, Koshimizu T, Ohata Y, Tachikawa K, Mikuni-Takagaki Y, Kogo M, Ozono K, Michigami T. Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice. PLoS One. 2014;9(4):e93840.
  2. Ohata Y, Yamazaki M, Kawai M, Tsugawa N, Tachikawa K, Koinuma T, Miyagawa K, Kimoto A, Nakayama M, Namba N, Yamamoto H, Okano T, Ozono K, Michigami T. Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of Hyp mice. J Bone Miner Res. 2014;29(7):1627-1638.
  3. Kawai M*, Kinoshita S, Shimba S, Ozono K, Michigami T. Sympathetic activation induces skeletal Fgf23 expression in a circadian rhythm-dependent manner. J Biol Chem. 2014;289(3):1457-1466.
*: corresponding author

2013年

  1. Kondou H, Kawai M, Tachikawa K, Kimoto A, Yamagata M, Koinuma T, Yamazaki M, Nakayama M, Mushiake S, Ozono K, Michigami T. Sodium-coupled neutral amino acid transporter 4 functions as a regulator of protein synthesis during liver development. Hepatol Res. 2013;43(11):1211-1223.
  2. Motyl KJ, Bishop KA, DeMambro VE, Bornstein SA, Le P, Kawai M, Lotinun S, Horowitz MC, Baron R, Bouxsein ML, Rosen CJ. Altered thermogenesis and impaired bone remodeling in Misty mice. J Bone Miner Res. 2013;28(9):1885-1897.
  3. Kawai M*, Kinoshita S, Kimoto A, Hasegawa Y, Miyagawa K, Yamazaki M, Ohata Y, Ozono K, Michigami T. FGF23 suppresses chondrocyte proliferation in the presence of soluble alpha-Klotho both in vitro and in vivo. J Biol Chem. 2013;288(4):2414-2427.
  4. Kawai M*. Adipose tissue and bone: role of PPARgamma in adipogenesis and osteogenesis. Horm Mol Biol Clin Investig. 2013;15(3):105-113.
*: corresponding author

2012年

  1. Koshimizu T, Kawai M, Kondou H, Tachikawa K, Sakai N, Ozono K, Michigami T. Vinculin functions as regulator of chondrogenesis. J Biol Chem. 2012;287(19):15760-15775.
  2. Le P, Kawai M, Bornstein S, DeMambro VE, Horowitz MC, Rosen CJ. A high-fat diet induces bone loss in mice lacking the Alox5 gene. Endocrinology. 2012;153(1):6-16.
  3. DeMambro VE, Maile L, Wai C, Kawai M, Cascella T, Rosen CJ, Clemmons D. Insulin-like growth factor-binding protein-2 is required for osteoclast differentiation. J Bone Miner Res. 2012;27(2):390-400.
  4. Kawai M, de Paula FJ, Rosen CJ. New insights into osteoporosis: the bone-fat connection. J Intern Med. 2012;272(4):317-329.
  5. Kawai M, Rosen CJ. The insulin-like growth factor system in bone: basic and clinical implications. Endocrinol Metab Clin North Am. 2012;41(2):323-333, vi.

2011年

  1. Guntur AR, Kawai M, Le P, Bouxsein ML, Bornstein S, Green CB, Rosen CJ. An essential role for the circadian-regulated gene nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasis. Ann N Y Acad Sci. 2011;1237:58-63.
  2. Kawai M, Breggia AC, DeMambro VE, Shen X, Canalis E, Bouxsein ML, Beamer WG, Clemmons DR, Rosen CJ. The heparin-binding domain of IGFBP-2 has insulin-like growth factor binding-independent biologic activity in the growing skeleton. J Biol Chem. 2011;286(16):14670-14680.
  3. Kawai M, Modder UI, Khosla S, Rosen CJ. Emerging therapeutic opportunities for skeletal restoration. Nat Rev Drug Discov. 2011;10(2):141-156.

2010年

  1. Lecka-Czernik B, Rosen CJ, Kawai M. Skeletal aging and the adipocyte program: New insights from an "old" molecule. Cell Cycle. 2010;9(18):3648-3654.
  2. Kawai M, Sousa KM, MacDougald OA, Rosen CJ. The many facets of PPARgamma: novel insights for the skeleton. Am J Physiol Endocrinol Metab. 2010;299(1):E3-9.
  3. Kawai M, Rosen CJ. Bone: adiposity and bone accrual-still an established paradigm? Nat Rev Endocrinol. 2010;6(2):63-64.
  4. Kawai M, Rosen CJ. PPARgamma: a circadian transcription factor in adipogenesis and osteogenesis. Nat Rev Endocrinol. 2010;6(11):629-636.
  5. Kawai M, Rosen CJ. The IGF-I regulatory system and its impact on skeletal and energy homeostasis. J Cell Biochem. 2010;111(1):14-19.
  6. Kawai M, Rosen CJ. Minireview: A skeleton in serotonin's closet? Endocrinology. 2010;151(9):4103-4108.
  7. Kawai M, Green CB, Lecka-Czernik B, Douris N, Gilbert MR, Kojima S, Ackert-Bicknell C, Garg N, Horowitz MC, Adamo ML, Clemmons DR, Rosen CJ. A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation. Proc Natl Acad Sci U S A. 2010;107(23):10508-10513.
  8. Kawai M, Green CB, Horowitz M, Ackert-Bicknell C, Lecka-Czernik B, Rosen CJ. Nocturnin: a circadian target of Pparg-induced adipogenesis. Ann N Y Acad Sci. 2010;1192:131-138.
  9. Kawai M, Delany AM, Green CB, Adamo ML, Rosen CJ. Nocturnin suppresses igf1 expression in bone by targeting the 3' untranslated region of igf1 mRNA. Endocrinology. 2010;151(10):4861-4870.
  10. DeMambro VE, Kawai M, Clemens TL, Fulzele K, Maynard JA, Marin de Evsikova C, Johnson KR, Canalis E, Beamer WG, Rosen CJ, Donahue LR. A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis. J Endocrinol. 2010;204(3):241-253.

2009年以前

  1. Kawai M, Rosen CJ. Insulin-like growth factor-I and bone: lessons from mice and men. Pediatr Nephrol. 2009;24(7):1277-1285.
  2. Kawai M, Devlin MJ, Rosen CJ. Fat targets for skeletal health. Nat Rev Rheumatol. 2009;5(7):365-372.
  3. Kawai M, Namba N, Mushiake S, Etani Y, Nishimura R, Makishima M, Ozono K. Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway. J Mol Endocrinol. 2007;38(1-2):19-34.
  4. Kawai M, Mushiake S, Bessho K, Murakami M, Namba N, Kokubu C, Michigami T, Ozono K. Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARgamma and C/EBPalpha. Biochem Biophys Res Commun. 2007;363(2):276-282.
  5. Kawai M, Sakai N, Miyake S, Tsukamoto H, Akagi M, Inui K, Mushiake S, Taniike M, Ozono K. Novel mutation of gene coding for glial fibrillary acidic protein in a Japanese patient with Alexander disease. Brain Dev. 2006;28(1):60-62.
  6. Kawai M, Kubota A, Ida S, Yamamura Y, Yoshimura N, Takeuchi M, Nakayama M, Okuyama H, Oue T, Kawahara H, Okada A. Cow's milk allergy presenting Hirschsprung's disease-mimicking symptoms. Pediatr Surg Int. 2005;21(10):850-852.
  7. Kokubu C, Heinzmann U, Kokubu T, Sakai N, Kubota T, Kawai M, Wahl MB, Galceran J, Grosschedl R, Ozono K, Imai K. Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis. Development. 2004;131(21):5469-5480.
  8. Kawai M, Kawahara H, Hirayama S, Yoshimura N, Ida S. Effect of baclofen on emesis and 24-hour esophageal pH in neurologically impaired children with gastroesophageal reflux disease. J Pediatr Gastroenterol Nutr. 2004;38(3):317-323.
  9. Ohta H, Kawai M, Sawada A, Tokimasa S, Fujisaki H, Matsuda Y, Osugi Y, Okada S, Hara J. Juvenile myelomonocytic leukemia relapsing after allogeneic bone marrow transplantation successfully treated with interferon-alpha. Bone Marrow Transplant. 2000;26(6):681-683.

分子遺伝・内分泌代謝研究部門