代謝部門

業績

構成員が筆頭著者である原著論文

Asakawa D, Takeuchi T, Yamashita A, Wada Y. "Influence of Metal-Peptide Complexation on Fragmentation and Inter-Fragment Hydrogen Migration in Electron Transfer Dissociation" J Am Soc Mass Spectrom (in press)

Iwai K, Shibukawa Y, Yamazaki N, Wada Y. “Transglutaminase 2-dependent deamidation of glyceraldehyde-3-phosphate dehydrogenase promotes trophoblastic cell fusion” J Biol Chem. 2013 Dec 27. [Epub ahead of print] PMID: 24375405

Daimon E, Shibukawa Y, Wada Y. “Calponin 3 regulates stress fiber formation in dermal fibroblasts during wound healing” Arch Dermatol Res 305(7):571-584 (2013) doi: 10.1007/s00403-013-1343-8. Epub 2013 Apr 2. PMID: 23545751

Shibukawa Y, Yamazaki N, Daimon E, Wada Y. "Rock-dependent calponin 3 phosphorylation regulates myoblast fusion" Exp Cell Res. 319(5):633-648 (2013). Epub 2012 Dec 28. PMID: 23276748

Wada Y. “Label-free analysis of O-glycosylation site-occupancy based on the signal intensity of glycopeptide/peptide ions” Mass Spectrom (Tokyo). 2012;1(2):A0008. doi: 10.5702/massspectrometry.A0008. Epub 2012 Nov 2. PMID: 24349909

Wada Y, Kadoya M, Okamoto N. “Mass spectrometry of apolipoprotein C-III, a simple analytical method for mucin-type O-glycosylation, and its application to an autosomal recessive cutis laxa type-2 (ARCL2) patient” Glycobiology 22(8):1140-1144 (2012) PMID: 22611120 Epub 2012 May 18.

Tajiri M, Wada Y. "Infrared matrix-assisted laser desorption/ionization mass spectrometry for quantification of glycosaminoglycans and gangliosides" Int J Mass Spectrom 305: 164-169 (2011)

Shibukawa Y, Yamazaki N, Kumasawa K, Daimon E, Tajiri M, Okada Y, Ikawa M, Wada Y. “Calponin 3 regulates actin cytoskeleton rearrangement in trophoblastic cell fusion” Mol Biol Cell 21(22):3973-3984 (2010) PMID: 20861310

Wada Y, Dell A, Haslam SM, Tissot B, Canis K, Azadi P, Backstrom M, Costello CE, Hansson GC, Hiki Y, Ishihara M, Ito H, Kakehi K, Karlsson N, Kato K, Kawasaki N, Khoo KH, Kobayashi K, Kolarich D, Kondo A, Lebrilla C, Nakano M, Narimatsu H, Novak J, Novotny MV, Ohno E, Packer NH, Renfrow MB, Tajiri M, Thomsson KA, Yagi H, Yu SY, Taniguchi N. "Comparison of methods for profiling O-glycosylation: HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study of IgA1" Mol Cell Proteomics 9(4): 719-727 (2010) Apr (Epub 2009 Dec 28) PMID: 20038609

Wada Y, Tajiri M, Ohshima S. "Quantitation of saccharide compositions of O-glycans by mass spectrometry of glycopeptides and its application to rheumatoid arthritis" J Proteome Res 9(3):1367-1373 (2010) Mar-5 PMID: 20104905

Tajiri M, Takeuchi T, Wada Y. "Distinct features of matrix-assisted 6 μm infrared laser desorption/ionization mass spectrometry in biomolecular analysis" Anal Chem 81(16) 6750-6755 (2009) Aug-15 PMID: 19627133

Tajiri M. Kadoya M, Wada Y. “Dissociation profile of protonated fucosyl glycopeptides and quantitation of fucosylation levels of glycoproteins by mass spectrometry.” J Proteome Res 8(2), 688-693 (2009) Feb PMID: 19099505

Tajiri M, Ohyama C, Wada Y. “Oligosaccharide profiles of the prostate specific antigen in free and complexed forms from prostate cancer patient serum and in seminal plasma: a glycopeptide approach.” Glycobiology. 18, 2-8 (2008); 2007 Oct 23; [Epub ahead of print] PMID: 17956937

Wada Y, Yanagishita T, Masuda H. "Ordered porous alumina geometries and surface metals for surface-assisted laser desorption/ionization of biomolecules: Possible mechanistic implications of metal surface melting" Anal Chem 79, 9122-9127 (2007) PMID: 17979256

Wada Y. "Mass spectrometry in the detection and diagnosis of congenital disorders of glycosylation" Eur. J Mass Spectrom 13, 101-103 (2007)

Wada Y, Azadi P, Costello CE, Dell A, Dwek RA, Geyer H, Geyer R, Kakehi K, Karlsson NG, Kato K, Kawasaki N, Khoo KH, Kim S, Kondo A, Lattova E, Mechref Y, Miyoshi E, Nakamura K, Narimatsu H, Novotny MV, Packer NH, Perreault H, Peter-Katalinic J, Pohlentz G, Reinhold VN, Rudd PM, Suzuki A, Taniguchi N. "Comparison of the methods for profiling glycoprotein glycans?HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study" Glycobiology 17: 411-422 (2007) PMID: 17223647


他機関との共同研究成果としての原著論文

Takahashi M, Hasegawa Y, Ariki S, Asakawa D, Tajiri M, Wada Y, Yamaguchi Y, Nishitani C, Takamiya R, Saito A, Uehara Y, Hashimoto J, Kurimura Y, Takahashi H, Kuroki Y. “Surfactant protein D suppresses lung cancer progression by downregulation of epidermal growth factor signaling" Oncogene (in press)

Kihara M, Ito K, Nakata J, Otani M, Tran NL, Morito N, Takahashi S, Wada Y, Izui S. "O-Linked Glycosylation Determines the Nephritogenic Potential of IgA Rheumatoid Factor" J Am Soc Nephrol. 2014 Feb 7. [Epub ahead of print] PMID: 24511137

Tegtmeyer LC, Rust S, van Scherpenzeel M, Ng BG, Losfeld ME, Timal S, Raymond K, He P, Ichikawa M, Veltman J, Huijben K, Shin YS, Sharma V, Adamowicz M, Lammens M, Reunert J, Witten A, Schrapers E, Matthijs G, Jaeken J, Rymen D, Stojkovic T, Laforêt P, Petit F, Aumaître O, Czarnowska E, Piraud M, Podskarbi T, Stanley CA, Matalon R, Burda P, Seyyedi S, Debus V, Socha P, Sykut-Cegielska J, van Spronsen F, de Meirleir L, Vajro P, DeClue T, Ficicioglu C, Wada Y, Wevers RA, Vanderschaeghe D, Callewaert N, Fingerhut R, van Schaftingen E, Freeze HH, Morava E, Lefeber DJ, Marquardt T. “Multiple phenotypes in phosphoglucomutase 1 deficiency” N Engl J Med. 2014 Feb 6;370(6):533-42. doi: 10.1056/NEJMoa1206605. PMID: 24499211

Okuda H, Tatsumi K, Morita S, Shibukawa Y, Korekane H, Horii-Hayashi N, Wada Y, Taniguchi N, Wanaka A. "Chondroitin sulfate proteoglycan tenascin-R regulates glutamate uptake by adult brain astrocytes" J Biol Chem. 2014 Jan 31;289(5):2620-31. doi: 10.1074/jbc.M113.504787. Epub 2013 Dec 11. PMID: 24337573

Takahashi M, Hasegawa Y, Ikeda Y, Wada Y, Tajiri M, Ariki S, Takamiya R, Nishitani C, Araki M, Yamaguchi Y, Taniguchi N, Kuroki Y. “Suppression of heregulin beta signaling by single N-glycan deletion mutant of soluble ErbB3” J Biol Chem. 2013 Nov 15;288(46):32910-21. doi: 10.1074/jbc.M113.491902. Epub 2013 Oct 4. PMID: 24097984

Aoki H, Shiomi M, Ikeda T, Ishii T, Shimizu N, Togawa M, Okamoto N, Kadoya K, Wada Y. “Decreased sialylation of IgA1 O-glycans associated with pneumococcal hemolytic uremic syndrome” Pediatr Int. 2013 Dec;55(6):e143-5. doi: 10.1111/ped.12166. PMID: 24330298

Kodera H, Nakamura K, Osaka H, Maegaki Y, Haginoya K, Mizumoto S, Kato M, Okamoto N, Iai M, Kondo Y, Nishiyama K, Tsurusaki Y, Nakashima M, Miyake N, Hayasaka K, Sugahara K, Yuasa I, Wada Y, Matsumoto N, Saitsu H. “De novo mutations in SLC35A2 encoding a UDP-galactose transporter cause early-onset epileptic encephalopathy” Hum Mutat. 2013 Dec;34(12):1708-14. doi: 10.1002/humu.22446. Epub 2013 Oct 15. PMID: 24115232

Koehler K, Malik M, Mahmood S, Gießelmann S, Beetz C, Hennings JC, Huebner AK, Grahn A, Reunert J, Nürnberg G, Thiele H, Altmüller J, Nürnberg P, Mumtaz R, Babovic-Vuksanovic D, Basel-Vanagaite L, Borck G, Brämswig J, Mühlenberg R, Sarda P, Sikiric A, Anyane-Yeboa K, Zeharia A, Ahmad A, Coubes C, Wada Y, Marquardt T, Vanderschaeghe D, Van Schaftingen E, Kurth I, Huebner A, Hübner CA. "Mutations in GMPPA Cause a Glycosylation Disorder Characterized by Intellectual Disability and Autonomic Dysfunction" Am J Hum Genet. 93(4):727-734, 2013. doi: 10.1016/j.ajhg.2013.08.002. Epub 2013 Sep 12. PMID: 24035193

Leymarie N, Griffin PJ, Jonscher K, Kolarich D, Orlando R, McComb M, Zaia J, Aguilan J, Alley WR, Altmann F, Ball LE, Basumallick L, Bazemore-Walker CR, Behnken H, Blank MA, Brown KJ, Bunz SC, Cairo CW, Cipollo JF, Daneshfar R, Desaire H, Drake RR, Go EP, Goldman R, Gruber C, Halim A, Hathout Y, Hensbergen PJ, Horn DM, Hurum D, Jabs W, Larson G, Ly M, Mann BF, Marx K, Mechref Y, Meyer B, Möginger U, Neusüss C, Nilsson J, Novotny MV, Nyalwidhe JO, Packer NH, Pompach P, Reiz B, Resemann A, Rohrer JS, Ruthenbeck A, Sanda M, Schulz JM, Schweiger-Hufnagel U, Sihlbom C, Song E, Staples GO, Suckau D, Tang H, Thaysen-Andersen M, Viner RI, An Y, Valmu L, Wada Y, Watson M, Windwarder M, Whittal R, Wuhrer M, Zhu Y, Zou C. “Interlaboratory Study on Differential Analysis of Protein Glycosylation by Mass Spectrometry: the ABRF Glycoprotein Research Multi-Institutional Study 2012” Mol Cell Proteomics. 12(10):2935-2951, 2013. doi: 10.1074/mcp.M113.030643. Epub 2013 Jun 13. PMID: 23764502

Sano M, Korekane H, Ohtsubo K, Yamaguchi Y, Kato M, Shibukawa Y, Tajiri M, Adachi H, Wada Y, Asahi M, Taniguchi N. “N-glycans of SREC-I (Scavenger receptor expressed by endothelial cells) : Essential role for ligand binding, trafficking and stability” Glycobiology. 2012 Jan 25. [Epub ahead of print] PMID: 22279061

Kuga A, Kanagawa M, Sudo A, Chan YM, Tajiri M, Manya H, Kikkawa Y, Nomizu M, Kobayashi K, Endo T, Lu QL, Wada Y, Toda T. “Absence of post-phosphoryl modification in dystroglycanopathy mouse models and wild-type tissues expressing a non-laminin binding form of alpha-dystroglycan” J Biol Chem. 2012 Jan 23. [Epub ahead of print] PMID: 22270369

Inoue T, Iijima H, Tajiri M, Shinzaki S, Shiraishi E, Hiyama S, Mukai A, Nakajima S, Iwatani H, Nishida T, Mizushima T, Yasui T, Isaka Y, Kanto T, Tsujii M, Miyoshi M, Wada Y, Takehara T. “Deficiency of N-acetylgalactosamine in O-linked oligosaccharides of IgA is a novel biologic marker for Crohn’s disease” Inflamm Bowel Dis (in press) PMID: 22241690

Otani M, Nakata J, Kihara M, Leroy V, Moll S, Wada Y, Izui S. “O-glycosylated IgA rheumatoid factor induces IgA deposits and glomerulonephritis” J Am Soc Nephrol 23(3) 438-446 (2012) PMID: 22193386

Kitazume S, Tachida Y, Kato M, Yamaguchi Y, Honda T, Hashimoto Y, Wada Y, Saito T, Iwata N, Saido T, Taniguchi N. “Brain endothelial cells produce amyloid β from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form” J Biol Chem 285(51):40097-40103 (2010) PMID: 20952385

Hayakawa S, Matsumoto S, Hashimoto M, Iwamoto K, Nagao H, Toyoda M, Shigeri Y, Tajiri M, Wada Y.? “High-energy electron transfer dissociation (HE-ETD) using alkali metal targets for sequence analysis of post-translational peptides” J Am Soc Mass Spectrom 21(9):1482-1489 (2010) Epub 2010 Jun 9. PMID: 20598903